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Labelling of Chemicals (GHS) - Sixth revised edition
Version: 1.0
Creation Date: Aug 17, 2018
Revision Date: Aug 17, 2018
1.Identification
1.1GHS Product identifier
|
Product name |
letrozole |
1.2Other means of identification
|
Product number |
- |
|
Other names |
4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile |
1.3Recommended use of the chemical and restrictions on use
|
Identified uses |
For industry use only. |
|
Uses advised against |
no data available |
1.4Supplier's details
|
Company |
WuHan Dong Kang Yuan technology co., LTD |
|
Address |
15-401#，13-15 building,Wenhua Road,Zhifang Street,Jiangxia district,Wuhan |
|
Telephone |
027-81302411 |
|
Fax |
|
1.5Emergency phone number
|
Emergency phone number |
- |
|
Service hours |
Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
2.Hazard identification
2.1Classification of the substance or mixture
Reproductive toxicity, Category 1A
Specific target organ toxicity – repeated exposure, Category 2
2.2GHS label elements, including precautionary statements
|
Pictogram(s) |
|
|
Signal word |
Danger |
|
Hazard statement(s) |
H360 May damage fertility or the unborn child H373 May cause damage to organs through prolonged or repeated exposure |
|
Precautionary statement(s) |
|
|
Prevention |
P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P280 Wear protective gloves/protective clothing/eye protection/face protection. P260 Do not breathe dust/fume/gas/mist/vapours/spray. |
|
Response |
P308+P313 IF exposed or concerned: Get medical advice/ attention. P314 Get medical advice/attention if you feel unwell. |
|
Storage |
P405 Store locked up. |
|
Disposal |
P501 Dispose of contents/container to ... |
2.3Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1Substances
|
Chemical name |
Common names and synonyms |
CAS number |
EC number |
Concentration |
|
letrozole |
letrozole |
112809-51-5 |
none |
100% |
4.First-aid measures
4.1Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2Most important symptoms/effects, acute and delayed
no data available
4.3Indication of immediate medical attention and special treatment needed, if necessary
no data available
5.Fire-fighting measures
5.1Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2Specific hazards arising from the chemical
no data available
5.3Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
6.3Methods and materials for containment and cleaning up
Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
7.Handling and storage
7.1Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
8.Exposure controls/personal protection
8.1Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
|
Physical state |
white to off-whitecrystalline powder |
|
Colour |
no data available |
|
Odour |
no data available |
|
Melting point/ freezing point |
181-183ºC |
|
Boiling point or initial boiling point and boiling range |
374.4ºC at 760 mmHg |
|
Flammability |
no data available |
|
Lower and upper explosion limit / flammability limit |
no data available |
|
Flash point |
180.3ºC |
|
Auto-ignition temperature |
no data available |
|
Decomposition temperature |
no data available |
|
pH |
no data available |
|
Kinematic viscosity |
no data available |
|
Solubility |
no data available |
|
Partition coefficient n-octanol/water (log value) |
no data available |
|
Vapour pressure |
no data available |
|
Density and/or relative density |
1.21g/cm3 |
|
Relative vapour density |
no data available |
|
Particle characteristics |
no data available |
10.Stability and reactivity
10.1Reactivity
no data available
10.2Chemical stability
Stable under recommended storage conditions.
10.3Possibility of hazardous reactions
no data available
10.4Conditions to avoid
no data available
10.5Incompatible materials
no data available
10.6Hazardous decomposition products
no data available
11.Toxicological information
Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2Persistence and degradability
no data available
12.3Bioaccumulative potential
no data available
12.4Mobility in soil
no data available
12.5Other adverse effects
no data available
13.Disposal considerations
13.1Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
14.Transport information
14.1UN Number
|
ADR/RID: no data available |
IMDG: no data available |
IATA: no data available |
14.2UN Proper Shipping Name
|
ADR/RID: no data available |
|
IMDG: no data available |
|
IATA: no data available |
14.3Transport hazard class(es)
|
ADR/RID: no data available |
IMDG: no data available |
IATA: no data available |
14.4Packing group, if applicable
|
ADR/RID: no data available |
IMDG: no data available |
IATA: no data available |
14.5Environmental hazards
|
ADR/RID: no |
IMDG: no |
IATA: no |
14.6Special precautions for user
no data available
14.7Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1Safety, health and environmental regulations specific for the product in question
|
Chemical name |
Common names and synonyms |
CAS number |
EC number |
|
letrozole |
letrozole |
112809-51-5 |
none |
|
European Inventory of Existing Commercial Chemical Substances (EINECS) |
Not Listed. |
||
|
EC Inventory |
Not Listed. |
||
|
United States Toxic Substances Control Act (TSCA) Inventory |
Not Listed. |
||
|
China Catalog of Hazardous chemicals 2015 |
Not Listed. |
||
|
New Zealand Inventory of Chemicals (NZIoC) |
Listed. |
||
|
Philippines Inventory of Chemicals and Chemical Substances (PICCS) |
Not Listed. |
||
|
Vietnam National Chemical Inventory |
Not Listed. |
||
|
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) |
Not Listed. |
||
16.Other information
Information on revision
|
Creation Date |
Aug 17, 2018 |
|
Revision Date |
Aug 17, 2018 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
